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HEAD AN NECK SQUAMOUS CELL CANCERS – EMERGING TARGETED THERAPIES

HEAD AN NECK SQUAMOUS CELL CANCERS – EMERGING TARGETED THERAPIES

Systemic therapy remains the cornerstone of treatment for recurrent and metastatic (R/M) head and neck squamous cell cancers (HNSCC). However, there is a dearth of effective treatments beyond platinum combinations, anti-programmed death-1 (PD-1) agents and the epidermal growth factor receptor (EGFR)-targeting monoclonal antibody cetuximab. Recent years have seen several exciting new agents being tested in clinical trials. These are designed to target alternate oncogenic signaling pathways and have novel mechanistic compositions, including bi-specific antibodies and antibody-drug conjugates. 

A new study published in Frontiers delves into the clinical limitations of currently approved systemic therapies, explores novel agents in development, and highlights ongoing clinical trials using targeted therapies for this disease.

https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1640960/full

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